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In vivo CAR-T Platform
In vivo CAR-T therapy is revolutionizing adoptive cell therapy by bypassing the need for ex vivo T-cell engineering. Instead, genetic materials like CAR-encoding mRNA are delivered directly into the patient—typically via lipid nanoparticles (LNPs)—streamlining manufacturing, cutting costs and time, and enabling scalable, off-the-shelf treatments.
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Levostar Biotech empowers the next generation of in vivo CAR-T cell therapies with a fully integrated platform designed to streamline development and scale-up. Our end-to-end solutions encompass monoplasmid, IVT mRNA synthesis, and advanced LNP encapsulation, ensuring seamless translation from concept to clinic.
One-Stop Solution
Applications of In vivo CAR-T
In vivo CAR-T technologies are enabling new therapeutic opportunities across a variety of indications:
● Hematological malignancies
● Solid tumors
● Autoimmune diseases
● Infectious diseases
● Off-the-shelf allogeneic therapy
FAQ
What is in vivo CAR-T therapy and how is it different from ex vivo CAR-T?
In vivo CAR-T therapy is an emerging approach that enables CAR-T cell generation directly inside the patient’s body, eliminating the need for complex ex vivo cell isolation, engineering, and reinfusion.Unlike traditional ex vivo CAR-T therapy, which requires labor-intensive manufacturing and long turnaround times, in vivo CAR-T leverages delivery systems such as mRNA and lipid nanoparticles (LNPs) to introduce CAR constructs directly into T cells in vivo. This approach has the potential to reduce cost, shorten timelines, and improve scalability.
How can CAR-T cells be generated in vivo using non-viral delivery?
Non-viral in vivo CAR-T generation typically relies on mRNA delivery systems, such as lipid nanoparticles (LNPs), to transport CAR-encoding sequences into T cells.Once delivered, the mRNA is translated into CAR proteins inside the cells, enabling temporary CAR expression without the use of viral vectors. This method avoids risks associated with viral integration while allowing controlled and repeatable dosing strategies.
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Get in Touch with Levostar
Please send us your request or email to support@levostar.com, our team will contact you as soon as possible.
E-mail：support@levostar.com
USA
16192 Coastal Hwy，Lewes, DE 19958
TEL：619-537-9202
China
A3-502 No.328, Xinghu Street, Suzhou Industrial Park, Suzhou, Jiangsu, China 215123
TEL：0512-62888898